For the treatment and control of tick infestations with Amblyomma americanum (lone star tick) and Ixodes scapularis . Bentlee has been fine for 12 + hours in the house while I was stuck at work and never a drop of anything in the house. I will not in good conscience continue to give my three previously healthy dogs anymore Simparica Trio as it causing Gand Mal seizures in my older dog and nausea , vomiting and severe thirst and dehydration. You seem like an idiot. It was 11:30 pm . So now after $90.00 spent on three pills this month, I decide to look up the answers myself. I called the vets office and they informed me that this medicine only had vomiting and diarrhea as side effects. Your pets condition worsens or does not improve with treatment, You have additional questions or concerns about the use of Simparica or Simparica Trio. Eight hours later and she has terrible diarrhea and vomiting, now she is not eating. It could be something else that had caused her all the pain she went through but I surely will not give my puppy Simparica anymore and I hope she is alright. Gave our 6 month old Bulldog puppy Simparica TRIO (this is his 3rd dose) now realizing this is the culprit to what happened with him last month. Hes very lethargic and constant vomiting! This was January 15 of 2020. Furious that this out there for pets. Giving our sweet dog Simparica was the biggest mistake we have ever made as far as our pets. I'll be spreading the word. Ours lasted about a week. I was furious with the drug and the prescriber too. Them I took him to a vet for check up and to my horror, he has fleas and a tick. Since then I've researched loads and as you say the FDA put out a report. Simparica Trio is just one of many parasite prevention products on the market for dogs. Gave this to my dogs and now he sleeps all the time and tired and has symptoms now like droopy right side weakness cant blink right eye and drooling like bells palsy. And yeah he ate today 4 chicken breast and appeared to want it even better. He had kidney failure he had seizures he had nervous system problems. I am so worried about her I called to explain and was told to feed her chicken and rice and if she isn't improved take her to Emergency Vet Hospital. I'm so sorry. I to also gave my best friend Simparica as recommended by the vet. An neurological event took place again. My one year old has severe diarrhea and is very agitated and anxious. Thank u Fox I have good news I did get 2 additional in house potassium test done and they both came back normal. How can it not be the Simparica that did this to my baby when nothing else changed. She nearly died. My dog is experiencing these same symptoms and had his first accident in yearsss in the house and is drinking water excessively. I fell like hes dying right before my hands. This medication is generally well tolerated in most pets. Same as you describe. Previously B was on Heartgard and Advantix worked well I guess we switch back. She hasnt eaten in 3 days and is unable to go up 2 simple steps. the first puppy was still born looks to have died younger .my assumption when I gave lola that pill.she lost 1 puppy .the second baby is doing okay.although the vet said watch for neurological problems and GI problems. As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. Then gave me pills of prednisone for him to take 1 pill twice a day . My husband said that he felt like it would just make his coat shiny. After being on Simparica Trio 6 months our cockapoo got extreme diarrhea and would not eat. She's been given this dosage for over a year. Pharmaceuticals are killing people and pets. He protected our livestock from coyotes for many years and I took good care of him. Thanks! Does anyone know of anything we can give her to help get this out of her system? This medication should be banned and the company held responsible. Shortly after tablet I introduced sweet potatoes to diet per vet in lieu of potatoes. She has been treated by this clinic since birth. PROS Treats adult fleas and prevents flea and tick infestations Effective against five types of tick Liver flavored tablet FDA Approved CONS It is Easter Sunday and he still has diarrhea and drinking a crazy amount of water. 24 hours later she had another one. Simparica is only safe for dogs. As of today, Sadie's ability to eventually meet the strict certification requirements in that pursuit, remains guarded, although her progress prior to this event had been stellar. She has episodes where she seems very anxious and is hiding under car/tables/beds. I called the breeder, and she said some vaccines and heartworm meds can cause neurological issues. She still coughs, sneezes and brings up lots of mucus. A dog fence is an important detail to consider when adopting a pet for the first time or moving your dog to a new home. But this month we are at day 7 and I expect the diarrhea it to continue. Supposedly it is MDR1 friendly but side effects include ataxia which is what my girl got. Simparica is available by prescription only, so discuss any history your dog has of seizure disorders with your veterinarian when determining the best flea and tick treatment for your pet. We talked with Zoetis (the manufacturer of Simparica) after the FDA's announcement to get some concrete numbers on the frequency of these adverse reactions. I would NEVER recommend this medication. The affected dog must have been on Simparica Trio or Simparica for a minimum of 30 days prior to the report. Good luck. This is so scary. He just isnt himself. The same thing possibly is happening to my 9 month old Boxador. Best case scenario, he is able to come home, but we aren't there yet. What Are Potential Simparica Trio Side Effects in Dogs? The American Heartworm Society recommends year-round heartworm prevention for all dogs in the United States, and the Companion Animal Parasite Council recommends broad-spectrum parasite control to prevent heartworms, intestinal parasites, fleas, and ticks for all dogs in North America. Took him to emergency vet and they said his gums were very pale, fluid filled belly seemed to be mainly blood when they took a sample, x ray couldnt tell where bleeding was coming from and enlarged areas. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. I'll continue to watch her. Been also very lethargic not wanting to get out of bed. I just hope he has a turn around . Im at the 30 day mark from giving him the symparico and he no longer has pain but they want to continue him on a 4-6 months treatment of steroids as if its meningitis but I dont love the idea because the steroids have side effects too. I took my dog to the vet today and she received fluids and gabapentin. I give my dogs Simparica at the beginning of each month. On the first day he woke up and peed in my bedroom floor. Seems like it was directly related to the medication. I should have know it was a sign when he spat it out. Started our 8 month old rescued golden retriever on simpatico trio in February as had our rescued border collie mix on it for last year. Any tips on how to flush it from her system ? I disagree. He is just laying in his crate . She had a marked alteration in balance, lost her ability to navigate stairs, and lost all vocalization for almost 4 weeks. Thanks to its innovative formula, the treatment continues to work for 35 days, providing long-lasting relief from parasites and the diseases they carry. The most common adverse reactions in clinical trials were vomiting and diarrhea. Now tremors started. The tablet contains three active ingredients - sarolaner, moxidectin, and pyrantel - that work together to kill and repel parasites. Currently, for Simparica, less than 0.01% of dogs taking this medication have experienced any neurologic side effects. ). I have been feeding her some white rice hoping it improves. She keeps running through the house as though looking for something. I gave my yellow Lab, Sophie, her first Simperica trio. I did find another one in New Hampshire but I know like everyone else that all we be negative just like all tests done so far. In very rare instances, mild side effects and irritations can occur for a short period of time. Are there any side effects to Simparica Trio? All medicines come with some potential risks and side effects, and pet owners should weigh the potential risks and benefits in consultation with a veterinarian. We gave our one year old Simparica tonight and he started having trimmers that lasted on and off for about 30 minutes. My poor puppy has to go under anesthesia on top of. like she wants me to fix it. Bella is very consistent and normally has two bowel movements but hubby noted an increase in bowel movements and their amounts. At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. When he lays in the sun you can see the bumps under his skin. But the wandering and "head pressing" it's called, where they just go into the corner or lean against a table leg or the wall. I wish I would have seen this conversation before giving my 8 year old Labrador Retriever his first dose of Simparica Trio on Wednesday March 31st! I hope these steps will prevent anyone else's pet having to endure this. Today he wont eat, is sleeping all day, and when he is up he is panting heavily. This is taken from the article printed above all these comments "Simparica works by impacting the nervous system of invertebrates such as fleas and ticks. He seemed okay with his next dose January 1, so we renewed the prescription, and I gave him the February dose too. before i even gave to my dog small doxie i asked the vet about it and they assured me it was safe since she was and i say was a healthy dog. He is 11 so I attributed his slowing down on walks to aging but now he is recently limping and at times has some trouble with jumping up on the bed. Benefits: Each tablet provides a full month of protection against fleas and ticks. Now his tail looks like a rat tail. Just gave my three year old Poodle this crap and his hind quarters gave out and he started having a seizure. I just want to cry! Oh Lord, back to finding another vet. Humans can get infected with certain intestinal parasites, and fleas sometimes bite people. Hello to everyone and I am so sorry we had to meet under these circumstances. I left a lot out but didnt want to make too lengthy post. Thank you all for speaking out on Simparica Trio that Bandfield Hospital pushed on our Toy Poodle. after a few months of this i decided to go back to Sentinel and Bravecto. He could not hold down any food or water. He is stumbling, not able to stand on tile or go in and out of house without tripping on steps. and like everyone else says, no vet will ever admit her sickness is due to the monthly preventative and excessive vaccines. This dog was my partner and friend. It's now March 23, he still has falls but not like at first. The reaction lasted less than 12 hours. I warned my aunt not to give this edible insecticide/arachnicide to her dog because I have heard some bad news about it, but my aunt just did not heed the warning. Now do you get the connection? Two weeks after first simparica dose.parasites gone. I am trying to remain confident that my poor girl will recover. And for those who have lost their fur babies I am so sorry for your lost. Many can cause nausea, vomiting and neurological side effects. I originally wanted to get Nexgard, but for some odd reason, when I had went to my vet to pick it up, instead they gave me this. He looked like he was having a seizure. The cardiologist found no heart condition that would cause this. well my lola went into labor xmas day. Hoping for good news with your pup!! I saw the neurologist yesterday who printed out a list of drugs that a dog with seizures should not take. FRIDAY, Sept. 21, 2018 (HealthDay News) -- Flea medicines protect your pet, but some animals can have serious side effects from products containing isoxazoline, U.S. health officials warn. Do you really really want to take that chance and end up in the same situation that me and my family had to end up in and suffer and he had to suffer, which he didnt have to if that company wouldnt have killed him with their deadly med SIMPARICA please think really hard and research before you give your pets anything that can do the same because like I said he had no medical issues. His blood work came back normal but the vet called me to ask if his simparica somehow coincided with time of the seizures. My 15 yr old doodle wasnt given bravecto because of reviews. Next day she seemed different, standing slightly strangely. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. Hi, we did a spinal tap and MRI, its not viral or bacterial, its called steroid responsive meningitis which essentially is the meninges inflaming on their own, but if you look in this thread youll see others reporting similar symptoms/diagnosis so I do think Simparica trio triggered/caused it. so what about her puppies I am so worried. Find the Right Simparica for your dog. By Sunday he is having liquid diarrhea! Around 9pm he was barely able to jump up onto the couch and was extremely hesitant to go up the steps. Call the FDA. I have another dog, but gave him Frontline and he's fine. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks. As with any medication, there is a potential for side effects when using alternatives to Simparica Trio. He said it would take care of ticks and Trifexis doesn't. No diarrhea or vomiting or seizures. I am keeping a close eye on her and will take her to the vet if she hasnt improved by tonight. He likely does not even have a seizure disorder- just a reaction to this de-wormer that I was assured over and over again was a great thing for him to take and couldn't possibly cause this! Just a little nervous !! I finally got him to eat some chicken and he threw that up 2 hours later. How common are Simparica side effects? This content shouldnt take the place of advice by your vet. Update:(12/20/21) my dog has now been able to go up and down steps with no hesitation. Since the weather was turning cold, I stopped giving her the Simparica until spring. Never had them ever and she's only 3 1/2 yrs old. AVOID THIS PILL! Then I gave it to her again the 3rd month and the same thing happened. Our boy Axel had been on Heartgard his entire life. Wow. I thought maybe it was just a allergy break out which she's never had this long now I'm wondering if she's continuing to have a reaction. Next she developed severe tremors. I sure hope he makes it! Bravecto 18. By June 7th, she had a rash over most of her body, itching and biting herself to bloody raw spots. I hope we get to the bottom of it as this is not fun. Just our own personal experience but I won't get burned again! They don't really have an answer for why this happens at all, or why some dogs get better and some don't. I am so sad to read what is happening to some pets. Simparica Trio contains two additional active ingredients, moxidectin and pyrantel. No simparica for them either! She walks around as if she is on ice with no control of her back legs. I took him to the emergency hosp. This is still going on weeks later. I also am seeking information as to if there is a class action suit against this company because there should be. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. During this period coincidentally I have noticed a change in his behaviour. Hi Laura, How is you pup doing one after getting off simparica? He has trouble raising his leg to urinate. Read the package insert and it does list tremors and seizures as a side effect. I feel horrible for listening to the vet without researching this on my own. I gave the 1st one to my dog, 1st of this month. She falls when she runs and when going up and down stairs. All the swelling went down immediately and the itching went away too. My 18 month old dog has had Sim Perica trio. When we took him to the emergency vet they waved us off when we brought in the package, inquiring if it was the cause. with 801 Deaths and 1728 Seizures. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. Sorry for the late replywe took our boy to the ER and after 2 days on fluids and a shot of Percorton, he was diagnosed with Addison's Disease. I started giving my aussie shepherd simparica at 4 months. I am so mad at myself and so upset that I am the one that has made him sick. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. After about 35 days he was back to normal. I started crying carrying his body to my husband . . He has been on just Simparica with no problems. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. She had some itching and a bit lethargic but is eating very well. Many people have reported this as only temporary. Mine has tremors once in a while and now I know why! However, they are possible, so it is better to know they might happen. It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . This was the only thing we changed, I am convinced this is what did it to her. I am sure simparica caused a fatal seizure in my boxer. He has never acted like he was in pain. Zoetis (Simparica, Simparica Trio, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see How to Report Animal Drug and Device Side Effects and Product Problems. First dose was on 4/1 and 9 days later he was vomiting goop (yellow thick goo), he would drink water and vomit. 24 hours after, we noticed diarrhea. Nothing stopped the seizures and our Pickles passed away after just a few months of symptoms. She gets anxious and paces if I run into the grocery store even though my husband sits in the car with her. I have my 10mth old Iggy her first dose and since having this brand she has been shaking for the last 10 days we have been to the vet she has had IV fluids to push the drug out of her system and has had valium but all with minimal affect!!! The door is open , its where he prefers to sleep on a doggie bed . I don't know if the lump came from it or something else. Last month she had diarrhea and it lasted 7 days. Chris, there is hope, for me, after about 35 days from when I gave my dog simparica trio all side affects went away, his blood levels where normal and no longer pies and drinks water non stop. and lack of appetite. The following day she got diarrhea and was extreemly quiet. My 3 other poodles unaffected. The following day he would not even drink water. It is like night and day compared to her regular personality or demeanor. I dont know whether its a coincidence or not, but 4 days after second dose of Simparica Trio, my dog ended up at an urgent care with blood in his urine. The vet suggested this medication for my 9+ yr old English Bulldog. Duke is 7 month boxer And we have the simpatica on Monday and cant believe this stools Hopefully it doesnt last long. Each month he got sicker and sicker. My 8 month old labradoodle has had 2 doses of Simparico Trio. So, again, tears in my heart, THANK YOU ALL SO MUCH for your generous information. oh I should mention shadow is our 8 yr old dogue de Bordeaux - he has never had a reaction to anything ever before in his life and has never needed a vet so this was not usual at all for him .. My beautiful Golden was switched from her previous Medicine to this one. High on the list was Simparica Trio. No more itching but covered in same scabs. The only thing we changed after his checkup if Feb. was his flea and tick treatment. Hoping that these side effects dont get worse and subside soon . The next month on a sunny weekend, we have him his meds and took him on a walk with his basket muzzle. I wish I would have seen this site before I gave it my Matty. This has gone on for about half of the day. Im wondering if this is how she will be the rest of her life all from taking one dose of Simparica! No more of this poison for him. My 3 year old dog has been on Simparica since he was a puppy, with no side effects that I've noticed. He is disoriented, his head just hangs and he is lifeless. He is very whinny and is drinking a lot of water. Lost all appetite. The cost of Simparica Trio generally ranges from $2230 per dose depending on the tablet size, number of doses, and source of purchase. We will have blood work and results this evening. He ran bloods and sent her home with Keppra three times a day, after two weeks she is now down to twice a day. Not sure what effects he will continue to have. So you can imagine my worry now. I thought the first one it happened to may have gotten something in her eye but then a few days later the other had the same issue. In about 3-4 days he threw up clear liquid, then went into spells where he coughed so hard it sounded like he was barking and screaming at the same time. Prednisone helped symptoms in our case but the seizures kept going even after stopping this horrible med. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders. Im beside myself with guilt and fear. All antiparasitics for dogs lower the seizure threshold. (My first warning sign right there). My dog is having seizures. My dog is still having tremors 5 months after taking Simparica. Will be talking to the vet inregards to his side effects. Way too much of a coincidence. Gave our 23 month old Black Lab. Hopefully there are many other dogs that are unaffected, and just aren't written about here. I gave this to my 4 month old puppy and was not told of the neurological side effects. Shame on me for trusting the doctors that shrug off their responsibilities to the office girls for one thing. Random vomitting is no fun either. My dog is 9 yrs old . Yesterday one baby threw up four times within one hour of taking her chewable. He now cannot go in the car anymore. She didn't make it to the next day and died overnight. He also had a blood test done and all was normal. In our case the damage was permanent. However, doing nothing is better than giving her the Simparica. We rushed him to the emergency vet and they put him on keppra to stop the seizures. I am worried! My 2 1/2 mini goldendoodle has been on Simparica 10 days now. No more of this junk for my pups! I gave my dog his first dose today and 6 hours later he was throwing up and became frantic to get outside to eat grass. Sarolaner is effective against the following tick species: Moxidectin is an antiparasitic drug in the macrocyclic lactone class. He had a problem with severe biting a few months back and Vet said he most likely allergic to fleas (bites). When GABA attaches to a protein in your brain known as a GABA receptor, it produces a calming effect. Would appreciate any opinion you all may have. This is apparently not true and that's why the article never goes on to explain exactly why it only works on GABA receptors in fleas and ticks yet not affect the GABA receptors in your dog. Seizures continue and its Monday. Our guy is having pain and is showing arthritic symptoms. My 5 year old Bichon Frises, Ivy, was on NextGard for years. My dog has had 3 seizures in the past from wearing a flea collar. https://photos.app.goo.gl/GbP8UmDNBAxJ1m4g8 I feel like we are just waiting for him to pass now. About 11 months ago our vet recommended Simparica Trio. She seems more anxious now and really attached to hubby. not eating alor and wants me to rub her tummy constantly . Some dogs improve, some don't, not a clear answer why. Eyes roll back. Mine passed within 24 hours of the first dose. But im 99% sure the simparica is what caused it. In addition to killing fleas and several kinds of ticks, Simparicais effective in preventing and treating mange and ear mites. I take her everywhere as I'm terrified of it happening and her dying, we were convinced she was dying. It seemed impossible that our boy could age years in literally 3 days. I'm besides myself. I have been telling everyone not to give this to their furry ones!!!!!!!! Gastrointestinal Issues: Some dogs may experience diarrhea, vomiting, or a decreased appetite after taking Simparica Trio. Daily Paws is part of the Meredith National Digital Network. This is an eye opener for me! If undiagnosed he would have died. Skin issues. From classic to celeb-inspired and funny to food-based, this list of cute cat names is sure to inspire your naming adventures. Even ones on tv, he is shaking for an hour. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. Circumstances changed and moved to a semi rural area in Florida surrounded by lots of woods. The personality change is what has me most concerned too. Mine is due for another dose next week and I don't know what to do. My beautiful boxer lost his appetite after just one dose of Simparica. we gave our dane Simperica Brown about a day or so ago and all the sudden my sweet girl is having seizures. Blood work + urine sample. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications. Today the seizure like attack happened even though he is on the steroids. It has been five days and the diarrhea started on day 2. They watched him for a few hours and sent us on our way with a bill, again citing that he must have ate something. My vet recommended this for my puppy, he is now lethargic, has blood in stool, and can hardly stay awake. It still makes me sick to think about her last month we miss her so much. One has done great only notice that he is drinking a lot of water. 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